Adjudication of etiology of acute kidney injury: experience from the TRIBE-AKI multi-center study.

ABSTRACT:

Background

Adjudication of patient outcomes is a common practice in medical research and clinical trials. However minimal data exists on the adjudication process in the setting of Acute Kidney Injury (AKI) as well as the ability to judge different etiologies (e.g. Acute Tubular Necrosis (ATN), Pre-renal Azotemia (PRA)).

Methods

We enrolled 475 consecutive patients undergoing cardiac surgery at four sites of the Translational Research Investigating Biomarker Endpoints in AKI (TRIBE-AKI) study. Three expert nephrologists performed independent chart review, utilizing clinical variables and retrospective case report forms with pre intra and post-operative data, and then adjudicated all cases of AKI (n = 67). AKI was defined as a > 50% increase in serum creatinine for baseline (R

SUBMITTER: Koyner JL 

PROVIDER: S-EPMC4091753 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature