Differential promoter methylation of kinesin family member 1a in plasma is associated with breast cancer and DNA repair capacity.

ABSTRACT: Methylation alterations of CpG islands, CpG island shores and first exons are key events in the formation and progression of human cancer, and an increasing number of differentially methylated regions and genes have been identified in breast cancer. Recent studies of the breast cancer methylome using deep sequencing and microarray platforms are providing a novel insight on the different roles aberrant methylation plays in molecular subtypes of breast cancer. Accumulating evidence from a subset of studies suggests that promoter methylation of tumor-suppressor genes associated with breast cancer can be quantified in circulating DNA. However, there is a paucity of studies that examine the combined presence of genetic and epigenetic alterations associated with breast cancer using blood-based a

SUBMITTER: Guerrero-Preston R 

PROVIDER: S-EPMC4091885 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature