POWER-ENHANCED MULTIPLE DECISION FUNCTIONS CONTROLLING FAMILY-WISE ERROR AND FALSE DISCOVERY RATES.

ABSTRACT: Improved procedures, in terms of smaller missed discovery rates (MDR), for performing multiple hypotheses testing with weak and strong control of the family-wise error rate (FWER) or the false discovery rate (FDR) are developed and studied. The improvement over existing procedures such as the Šidák procedure for FWER control and the Benjamini-Hochberg (BH) procedure for FDR control is achieved by exploiting possible differences in the powers of the individual tests. Results signal the need to take into account the powers of the individual tests and to have multiple hypotheses decision functions which are not limited to simply using the individual p-values, as is the case, for example, with the Šidák, Bonferroni, or BH procedures. They also enhance understanding of the role of the po

SUBMITTER: Pena EA 

PROVIDER: S-EPMC4091923 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature