Biological heterogeneity in ADNI amnestic mild cognitive impairment.

ABSTRACT:

Background

Previous work examining normal controls from the Alzheimer's Disease Neuroimaging Initiative (ADNI) identified substantial biological heterogeneity. We hypothesized that ADNI mild cognitive impairment (MCI) subjects would also exhibit heterogeneity with possible clinical implications.

Methods

ADNI subjects diagnosed with amnestic MCI (n=138) were clustered based on baseline magnetic resonance imaging, cerebrospinal fluid, and serum biomarkers. The clusters were compared with respect to longitudinal atrophy, cognitive trajectory, and time to conversion.

Results

Four clusters emerged with distinct biomarker patterns: The first cluster was biologically similar to normal controls and rarely converted to Alzheimer's disease (AD) during follow-up. The second clus

SUBMITTER: Nettiksimmons J 

PROVIDER: S-EPMC4092059 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature