Microfluidic assembly of multistage porous silicon-lipid vesicles for controlled drug release.

ABSTRACT: A reliable microfluidic platform for the generation of stable and monodisperse multistage drug delivery systems is reported. A glass-capillary flow-focusing droplet generation device was used to encapsulate thermally hydrocarbonized porous silicon (PSi) microparticles into the aqueous cores of double emulsion drops, yielding the formation of a multistage PSi-lipid vesicle. This composite system enables a large loading capacity for hydrophobic drugs.

SUBMITTER: Herranz-Blanco B 

PROVIDER: S-EPMC4092317 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature