Risk of gastric cancer is associated with PRKAA1 gene polymorphisms in Koreans.

ABSTRACT:

Aim

To evaluate the association between genetic polymorphisms of the gene encoding AMP-activated protein kinase (PRKAA1) and the risk of gastric cancer.

Methods

The study subjects consisted of 477 age- and sex-matched case-control pairs. Genotyping was performed for 5 tag single nucleotide polymorphisms (SNPs): rs13361707, rs154268, rs3805486, rs6882903, and rs10074991. Associations between gastric cancer and putative risk factors (including the SNPs) were analyzed with multivariate conditional logistic regression models, after adjusting for potential confounding factors. Multiple testing corrections were implemented following methodology for controlling the false discovery rate. Gene-based association tests were performed by using the versatile gene-based association study

SUBMITTER: Kim YD 

PROVIDER: S-EPMC4093708 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature