Heparin microparticle effects on presentation and bioactivity of bone morphogenetic protein-2.

ABSTRACT: Biomaterials capable of providing localized and sustained presentation of bioactive proteins are critical for effective therapeutic growth factor delivery. However, current biomaterial delivery vehicles commonly suffer from limitations that can result in low retention of growth factors at the site of interest or adversely affect growth factor bioactivity. Heparin, a highly sulfated glycosaminoglycan, is an attractive growth factor delivery vehicle due to its ability to reversibly bind positively charged proteins, provide sustained delivery, and maintain protein bioactivity. This study describes the fabrication and characterization of heparin methacrylamide (HMAm) microparticles for recombinant growth factor delivery. HMAm microparticles were shown to efficiently bind several heparin-bindin

SUBMITTER: Hettiaratchi MH 

PROVIDER: S-EPMC4093826 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature