Injectable and oral contraceptives and risk of HIV acquisition in women: an analysis of data from the MDP301 trial.

ABSTRACT:

Study question

Do injectable and oral contraceptives increase the risk of human immunodeficiency virus (HIV) acquisition in women?

Summary answer

After adjusting for confounders, evidence of a significantly increased risk of HIV remained for women using injectable depo-medroxyprogesterone (DMPA) (hazard ratio = 1.49, 95% confidence interval (1.06-2.08)) but not for injectable norethisterone-enanthate (Net-En) or oral contraceptive pills (OC).

What is known already

An association between the use of some types of hormonal contraception (HC) methods and an increased risk of HIV, possibly through changes in the genital tract environment and alterations in the immune response, has been previously observed, although not consistently. A recent systematic review of these stud

SUBMITTER: Crook AM 

PROVIDER: S-EPMC4093991 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature