Incidence of multidrug-resistant tuberculosis disease in children: systematic review and global estimates.

ABSTRACT:

Background

Multidrug-resistant tuberculosis threatens to reverse recent reductions in global tuberculosis incidence. Although children younger than 15 years constitute more than 25% of the worldwide population, the global incidence of multidrug-resistant tuberculosis disease in children has never been quantified. We aimed to estimate the regional and global annual incidence of multidrug-resistant tuberculosis in children.

Methods

We developed two models: one to estimate the setting-specific risk of multidrug-resistant tuberculosis among child cases of tuberculosis, and a second to estimate the setting-specific incidence of tuberculosis disease in children. The model for risk of multidrug-resistant tuberculosis among children with tuberculosis needed a systematic literature r

SUBMITTER: Jenkins HE 

PROVIDER: S-EPMC4094366 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature