Clinical characteristics and outcome of patients with neuroblastoma presenting genomic amplification of loci other than MYCN.

ABSTRACT:

Background

Somatically acquired genomic alterations with MYCN amplification (MNA) are key features of neuroblastoma (NB), the most common extra-cranial malignant tumour of childhood. Little is known about the frequency, clinical characteristics and outcome of NBs harbouring genomic amplification(s) distinct from MYCN.

Methods

Genomic profiles of 1100 NBs from French centres studied by array-CGH were re-examined specifically to identify regional amplifications. Patients were included if amplifications distinct from the MYCN locus were seen. A subset of NBs treated at Institut Curie and harbouring MNA as determined by array-CGH without other amplification was also studied. Clinical and histology data were retrospectively collected.

Results

In total, 56 patients were inc

SUBMITTER: Guimier A 

PROVIDER: S-EPMC4094484 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature