Genetic diversity and population structure of Plasmodium vivax in Central China.

ABSTRACT:

Background

In Central China the declining incidence of Plasmodium vivax has been interrupted by epidemic expansions and imported cases. The impact of these changes on the local parasite population, and concurrent risks of future resurgence, was assessed.

Methods

Plasmodium vivax isolates collected from Anhui and Jiangsu provinces, Central China between 2007 and 2010 were genotyped using capillary electrophoresis at seven polymorphic short tandem repeat markers. Spatial and temporal analyses of within-host and population diversity, population structure, and relatedness were conducted on these isolates.

Results

Polyclonal infections were infrequent in the 94 isolates from Anhui (4%) and 25 from Jiangsu (12%), with a trend for increasing frequency from 2008 to 2010 (2 to

SUBMITTER: Liu Y 

PROVIDER: S-EPMC4094906 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature