An integrated genomic approach identifies persistent tumor suppressive effects of transforming growth factor-β in human breast cancer.

ABSTRACT:

Introduction

Transforming growth factor-βs (TGF-βs) play a dual role in breast cancer, with context-dependent tumor-suppressive or pro-oncogenic effects. TGF-β antagonists are showing promise in early-phase clinical oncology trials to neutralize the pro-oncogenic effects. However, there is currently no way to determine whether the tumor-suppressive effects of TGF-β are still active in human breast tumors at the time of surgery and treatment, a situation that could lead to adverse therapeutic responses.

Methods

Using a breast cancer progression model that exemplifies the dual role of TGF-β, promoter-wide chromatin immunoprecipitation and transcriptomic approaches were applied to identify a core set of TGF-β-regulated genes that specifically reflect only the tumor-suppressor a

SUBMITTER: Sato M 

PROVIDER: S-EPMC4095608 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature