Nicotine dependence as a moderator of genetic influences on smoking cessation treatment outcome.

ABSTRACT:

Background

Genetic influences on smoking cessation treatment outcome may be affected by pretreatment patient characteristics. Nicotine dependence is arguably the most salient clinical factor in smoking cessation.

Methods

In this secondary analysis of clinical trial data (N=793), we examined nicotine dependence severity as a moderator of the effects of 1198 single nucleotide polymorphisms (SNPs) in 53 biologically-relevant gene regions on smoking cessation outcomes. P-values were adjusted to account for multiple correlated SNPs within a gene region; corrected system-wide significance was 5 × 10(-4).

Results

SNP × nicotine dependence interactions reached region-wide significance for several SNPs in the Dopamine Beta Hydroxylase (DBH) locus (0.0005

SUBMITTER: Leventhal AM 

PROVIDER: S-EPMC4095777 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature