Apolipoprotein E genotype and outcome in infants with hypoxic-ischemic encephalopathy.

ABSTRACT:

Background

Adults with the apolipoprotein E (APOE) gene alleles e4 and e2 are at high risk of poor neurological outcome after brain injury. The e4 allele has been associated with cerebral palsy (CP), and the e2 allele has been associated with worse neurological outcome with congenital heart disease. This study was done to test the hypothesis that the APOE genotype is associated with outcome among neonates who survive after hypoxic-ischemic encephalopathy (HIE).

Methods

We conducted a cohort study of infants who survived HIE and had 18-22 mo standardized neurodevelopmental evaluations to assess associations between disability and the APOE genotypes e3/e3, e4/-, and e2/-.

Results

A total of 139 survivors were genotyped. Of these, 86 (62%) were of the e3/e3, 41 (29%) wer

SUBMITTER: Cotten CM 

PROVIDER: S-EPMC4095992 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature