Aryl-substituted aminobenzimidazoles targeting the hepatitis C virus internal ribosome entry site.

ABSTRACT: We describe the exploration of N1-aryl-substituted benzimidazoles as ligands for the hepatitis C virus (HCV) internal ribosome entry site (IRES) RNA. The design of the compounds was guided by the co-crystal structure of a benzimidazole viral translation inhibitor in complex with the RNA target. Structure-binding activity relationships of aryl-substituted benzimidazole ligands were established that were consistent with the crystal structure of the translation inhibitor complex.

SUBMITTER: Ding K 

PROVIDER: S-EPMC4096041 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature