Cu-catalyzed fluorination of diaryliodonium salts with KF.

ABSTRACT: A mild Cu-catalyzed nucleophilic fluorination of unsymmetrical diaryliodonium salts with KF is described. This protocol preferentially fluorinates the smaller aromatic ligand on iodine(III). The reaction exhibits a broad substrate scope and proceeds with high chemoselectivity and functional group tolerance. DFT calculations implicate a Cu(I)/Cu(III) catalytic cycle.

SUBMITTER: Ichiishi N 

PROVIDER: S-EPMC4096328 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature