How to infer relative fitness from a sample of genomic sequences.

ABSTRACT: Mounting evidence suggests that natural populations can harbor extensive fitness diversity with numerous genomic loci under selection. It is also known that genealogical trees for populations under selection are quantifiably different from those expected under neutral evolution and described statistically by Kingman's coalescent. While differences in the statistical structure of genealogies have long been used as a test for the presence of selection, the full extent of the information that they contain has not been exploited. Here we demonstrate that the shape of the reconstructed genealogical tree for a moderately large number of random genomic samples taken from a fitness diverse, but otherwise unstructured, asexual population can be used to predict the relative fitness of individuals wi

SUBMITTER: Dayarian A 

PROVIDER: S-EPMC4096370 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature