Exploring the association of hemoglobin level and adverse events in children with cancer presenting with fever in neutropenia.

ABSTRACT:

Background

In children and adolescents with fever in neutropenia (FN) during chemotherapy for cancer, hemoglobin ≥90 g/L at presentation with FN had been associated with adverse events (AE). This analysis explored three hypothetical pathophysiological mechanisms potentially explaining this counterintuitive finding, and further analyzed the statistical association between hemoglobin and AE.

Methods

Two of 8 centers, reporting on 311 of 421 FN episodes in 138 of 215 patients participated in this retrospective analysis based on prospectively collected data from three databases (SPOG 2003 FN, transfusion and hematology laboratories). Associations with AE were analyzed using mixed logistic regression.

Results

Hemoglobin was ≥90 g/L in 141 (45%) of 311 FN episodes, specific

SUBMITTER: Ammann RA 

PROVIDER: S-EPMC4096594 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature