Halogenated diarylacetylenes repress c-myc expression in cancer cells.

ABSTRACT: Halogenated diarylacetylenes that possess fluorine or chlorine substituents in one aryl ring and N-methylamino or N,N-dimethylamino in the other aryl ring inhibit the proliferation of LS174T colon cancer cells through the repression of c-myc expression and induction of the cyclin-dependent kinase inhibitor-1 (i.e., p21(Wif1/Cip1)) and represent potentially useful antineoplastic agents.

SUBMITTER: Sviripa VM 

PROVIDER: S-EPMC4096707 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature