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Synthesis of the AviMeCys-containing D-ring of mersacidin.

ABSTRACT: A chemical synthesis of the D-ring of mersacidin is reported. The synthetic route relied upon development of a method for late-stage introduction of an unusual S-[(Z)-2-aminovinyl]-(3S)-3-methyl-D-cysteine (AviMeCys) functional group via an oxidative decarbonylation/decarboxylation reaction.

SUBMITTER: Carrillo AK 

PROVIDER: S-EPMC4096711 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature

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Synthesis of the AviMeCys-containing D-ring of mersacidin.

Carrillo Angela K AK   VanNieuwenhze Michael S MS  

Organic letters 20120201 4

A chemical synthesis of the D-ring of mersacidin is reported. The synthetic route relied upon development of a method for late-stage introduction of an unusual S-[(Z)-2-aminovinyl]-(3S)-3-methyl-D-cysteine (AviMeCys) functional group via an oxidative decarbonylation/decarboxylation reaction. ...[more]

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