Prenatal alcohol exposure alters expression of neurogenesis-related genes in an ex vivo cell culture model.

ABSTRACT: Prenatal alcohol exposure can lead to long-lasting changes in functional and genetic programs of the brain, which may underlie behavioral alterations seen in Fetal Alcohol Spectrum Disorder (FASD). Aberrant fetal programming during gestational alcohol exposure is a possible mechanism by which alcohol imparts teratogenic effects on the brain; however, current methods used to investigate the effects of alcohol on development often rely on either direct application of alcohol in vitro or acute high doses in vivo. In this study, we used our established moderate prenatal alcohol exposure (PAE) model, resulting in maternal blood alcohol content of approximately 20 mM, and subsequent ex vivo cell culture to assess expression of genes related to neurogenesis. Proliferating and differentiating neur

SUBMITTER: Tyler CR 

PROVIDER: S-EPMC4096774 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature