Aberrant error processing in relation to symptom severity in obsessive-compulsive disorder: A multimodal neuroimaging study.

ABSTRACT:

Background

Obsessive-compulsive disorder (OCD) is characterized by maladaptive repetitive behaviors that persist despite feedback. Using multimodal neuroimaging, we tested the hypothesis that this behavioral rigidity reflects impaired use of behavioral outcomes (here, errors) to adaptively adjust responses. We measured both neural responses to errors and adjustments in the subsequent trial to determine whether abnormalities correlate with symptom severity. Since error processing depends on communication between the anterior and the posterior cingulate cortex, we also examined the integrity of the cingulum bundle with diffusion tensor imaging.

Methods

Participants performed the same antisaccade task during functional MRI and electroencephalography sessions. We measured error-

SUBMITTER: Agam Y 

PROVIDER: S-EPMC4096999 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature