Early elevated serum gamma glutamyl transpeptidase after liver transplantation is associated with better survival.

ABSTRACT:

Background

Gamma glutamyl transpeptidase (GGT) is a membrane bound enzyme that plays a key role in the synthesis of the antioxidant glutathione. Epidemiological studies have linked high GGT with an increased risk of morbidity and cardiovascular mortality. In contrast, GGT is usually elevated in liver transplant recipients that experience good outcomes.

Aims

To study if and how GGT is correlated with mortality following liver transplantation.

Methods

We analyzed the prognostic relevance of serum GGT levels during the early and late postoperative period after liver transplantation in 522 consecutive adults. We also studied alanine aminotransferase, aspartate aminotransferase, and total bilirubin levels.

Results

Early after transplantation, the peak median (interq

SUBMITTER: Alkozai EM 

PROVIDER: S-EPMC4097359 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature