Preparing for an era of untreatable gonorrhea.

ABSTRACT:

Purpose of review

The proportion of Neisseria gonorrhoeae isolates with reduced susceptibility to extended-spectrum cephalosporins (ESCs) has increased rapidly since 2006. Clinicians, researchers, and public health officials need to be prepared for the possibility of an era of untreatable gonorrhea. This review focuses on the evidence for current gonorrhea treatment recommendations, potential future treatment options, and other methods to control gonorrhea.

Recent findings

In addition to an increase in isolates with decreased susceptibility to ESCs, there have been reported treatment failures to both cefixime and ceftriaxone. In response, some countries have increased the recommended cephalosporin dose, and most now recommend dual therapy with an ESC and azithromycin. The ph

SUBMITTER: Barbee LA 

PROVIDER: S-EPMC4097387 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature