Risk models for progression to advanced age-related macular degeneration using demographic, environmental, genetic, and ocular factors.

ABSTRACT:

Purpose

To expand our predictive models for progression to advanced stages of age-related macular degeneration (AMD) based on demographic, environmental, genetic, and ocular factors, using longer follow-up, time varying analyses, calculation of absolute risks, adjustment for competing risks, and detailed baseline AMD and drusen status.

Design

Prospective, longitudinal study.

Participants

We included 2937 individuals in the Age-Related Eye Disease Study, of which 819 subjects progressed to advanced AMD during 12 years of follow-up.

Methods

Cox proportional hazards regression analyses were performed to calculate hazard ratios for progression. Covariates included demographic and environmental factors, 6 variants in 5 genes, baseline macular drusen size, and presen

SUBMITTER: Seddon JM 

PROVIDER: S-EPMC4097877 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature