Analyzing longitudinal data to characterize the accuracy of markers used to select treatment.

ABSTRACT: With the increasing availability of detailed clinical information, there is optimism that treatment choices can be selectively directed to those individuals most likely to benefit. While standard clinical trials can establish whether a treatment appears to be effective on average, subsequent work is needed to determine whether there are identifiable subgroups of subjects for whom treatment is either particularly beneficial or harmful. Molecular assays and modern imaging technology now allow numerous candidate measures to be used as potential determinants of treatment choice. In this manuscript, we focus on novel measures of decision accuracy that reflect the treatment marker objective. Specifically, we define longitudinal individual-level potential outcomes (principal strata) that characte

SUBMITTER: Sitlani CM 

PROVIDER: S-EPMC4097886 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature