C-X-C motif chemokine 13 (CXCL13) is a prognostic biomarker of idiopathic pulmonary fibrosis.

ABSTRACT:

Rationale

C-X-C motif chemokine 13 (CXCL13) mediates B-cell trafficking and is increased, proportionately to disease activity, in many antibody-mediated syndromes. Dysregulated B cells have recently been implicated in idiopathic pulmonary fibrosis (IPF) pathogenesis.

Objectives

To determine if CXCL13 is associated with IPF progression.

Methods

CXCL13 was measured in lungs by DNA microarray and immunohistochemistry, and in plasma by ELISA.

Measurements and main results

CXCL13 mRNA was threefold and eightfold greater in IPF lungs (n = 92) compared with chronic obstructive pulmonary disease (COPD) (n = 191) and normal (n = 108) specimens, respectively (P < 0.0001). IPF lungs also showed increased CXCL13 staining. Plasma CXCL13 concentrations (pg/ml) were greater i

SUBMITTER: Vuga LJ 

PROVIDER: S-EPMC4098096 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature