Corticosteroids are associated with repression of adaptive immunity gene programs in pediatric septic shock.

ABSTRACT:

Rationale

Corticosteroids are prescribed commonly for patients with septic shock, but their use remains controversial and concerns remain regarding side effects.

Objectives

To determine the effect of adjunctive corticosteroids on the genomic response of pediatric septic shock.

Methods

We retrospectively analyzed an existing transcriptomic database of pediatric septic shock. Subjects receiving any formulation of systemic corticosteroids at the time of blood draw for microarray analysis were classified in the septic shock corticosteroid group. We compared normal control subjects (n = 52), a septic shock no corticosteroid group (n = 110), and a septic shock corticosteroid group (n = 70) using analysis of variance. Genes differentially regulated between the no corticoster

SUBMITTER: Wong HR 

PROVIDER: S-EPMC4098101 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature