Chronic LSD alters gene expression profiles in the mPFC relevant to schizophrenia.

ABSTRACT: Chronic administration of lysergic acid diethylamide (LSD) every other day to rats results in a variety of abnormal behaviors. These build over the 90 day course of treatment and can persist at full strength for at least several months after cessation of treatment. The behaviors are consistent with those observed in animal models of schizophrenia and include hyperactivity, reduced sucrose-preference, and decreased social interaction. In order to elucidate molecular changes that underlie these aberrant behaviors, we chronically treated rats with LSD and performed RNA-sequencing on the medial prefrontal cortex (mPFC), an area highly associated with both the actions of LSD and the pathophysiology of schizophrenia and other psychiatric illnesses. We observed widespread changes in the neurogene

SUBMITTER: Martin DA 

PROVIDER: S-EPMC4098645 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature