A comparison of tau and 14-3-3 protein in the diagnosis of Creutzfeldt-Jakob disease.

ABSTRACT:

Objective

To compare the respective efficiency of CSF tau (quantitative) and CSF 14-3-3 protein (qualitative) in the diagnosis of prion disease.

Methods

We made measurements on 420 live subjects, who subsequently underwent a postmortem neuropathology examination, including protein chemistry, immunohistochemistry, and histology. We performed tau by ELISA. We detected 14-3-3 protein by Western blot. Both assays were optimized for maximum efficiency (accuracy).

Results

We found tau and 14-3-3 proteins to be closely correlated, but tau had a significantly better ability to predict disease status than 14-3-3 protein. Also, tau distinguished disease status at least as well as when both assays' results are combined in a variety of ways. Importantly, the area under the receiv

SUBMITTER: Hamlin C 

PROVIDER: S-EPMC4098812 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature