Efficacy of antiepileptic drugs in adults predicts efficacy in children: a systematic review.

ABSTRACT:

Objective

Due to the challenges inherent in performing clinical trials in children, a systematic review of published clinical trials was performed to determine whether the efficacy of antiepileptic drugs (AEDs) in adults can be used to predict the efficacy of AEDs in the pediatric population.

Methods

Medline/PubMed, EMBASE, and Cochrane library searches (1970-January 2010) were conducted for clinical trials of partial-onset seizures (POS) and primary generalized tonic-clonic seizures (PGTCS) in adults and in children <2 and 2-18 years. Independent epidemiologists used standardized search and study evaluation criteria to select eligible trials. Forest plots were used to investigate the relative strength of placebo-subtracted effect measures.

Results

Among 30 adjunctive

SUBMITTER: Pellock JM 

PROVIDER: S-EPMC4098824 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature