Effect of diabetes mellitus type 2 on salivary glucose--a systematic review and meta-analysis of observational studies.

ABSTRACT:

Background

Early screening of type 2 diabetes mellitus (DM) is essential for improved prognosis and effective delay of clinical complications. However, testing for high glycemia often requires invasive and painful blood testing, limiting its large-scale applicability. We have combined new, unpublished data with published data comparing salivary glucose levels in type 2 DM patients and controls and/or looked at the correlation between salivary glucose and glycemia/HbA1c to systematically review the effectiveness of salivary glucose to estimate glycemia and HbA1c. We further discuss salivary glucose as a biomarker for large-scale screening of diabetes or developing type 2 DM.

Methods and findings

We conducted a meta-analysis of peer-reviewed published articles that reported da

SUBMITTER: Mascarenhas P 

PROVIDER: S-EPMC4098915 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature