XPC Lys939Gln polymorphism contributes to colorectal cancer susceptibility: evidence from a meta-analysis.

ABSTRACT:

Background

Published studies investigating the association between XPC Lys939Gln polymorphism and colorectal cancer (CRC) risk reported inconclusive results. We performed a meta-analysis to derive a precise estimation of the relationship.

Methods

A comprehensive literature search was done in databases PubMed, EMBASE, and Cochrane library up to December 2013. The association between XPC Lys939Gln polymorphism and CRC risk was assessed by odds ratios (ORs) together with their 95% confidence intervals (CIs).

Results

Eight studies with 3,301 cases and 4,177 controls were included in the meta-analysis. We observed that the XPC Lys939Gln polymorphism was correlated with an increased CRC risk when all studies were pooled into the meta-analysis (Gln/lys vs. Lys/Lys: OR = 1.29

SUBMITTER: Peng Q 

PROVIDER: S-EPMC4098961 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature