Oral microbiota distinguishes acute lymphoblastic leukemia pediatric hosts from healthy populations.

ABSTRACT: In leukemia, oral manifestations indicate aberrations in oral microbiota. Microbiota structure is determined by both host and environmental factors. In human hosts, how health status shapes the composition of oral microbiota is largely unknown. Taking advantage of advances in high-throughput sequencing, we compared the composition of supragingival plaque microbiota of acute lymphoblastic leukemia (ALL) pediatric patients with healthy controls. The oral microbiota of leukemia patients had lower richness and less diversity compared to healthy controls. Microbial samples clustered into two major groups, one of ALL patients and another of healthy children, with different structure and composition. Abundance changes of certain taxa including the Phylum Firmicutes, the Class Bacilli, the Order L

SUBMITTER: Wang Y 

PROVIDER: S-EPMC4099009 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature