Single nucleotide polymorphisms with cis-regulatory effects on long non-coding transcripts in human primary monocytes.

ABSTRACT: We applied genome-wide allele-specific expression analysis of monocytes from 188 samples. Monocytes were purified from white blood cells of healthy blood donors to detect cis-acting genetic variation that regulates the expression of long non-coding RNAs. We analysed 8929 regions harboring genes for potential long non-coding RNA that were retrieved from data from the ENCODE project. Of these regions, 60% were annotated as intergenic, which implies that they do not overlap with protein-coding genes. Focusing on the intergenic regions, and using stringent analysis of the allele-specific expression data, we detected robust cis-regulatory SNPs in 258 out of 489 informative intergenic regions included in the analysis. The cis-regulatory SNPs that were significantly associated with allele-specifi

SUBMITTER: Almlof JC 

PROVIDER: S-EPMC4099216 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature