Translational selection in human: more pronounced in housekeeping genes.

ABSTRACT:

Background

Translational selection is a ubiquitous and significant mechanism to regulate protein expression in prokaryotes and unicellular eukaryotes. Recent evidence has shown that translational selection is weakly operative in highly expressed genes in human and other vertebrates. However, it remains unclear whether translational selection acts differentially on human genes depending on their expression patterns.

Results

Here we report that human housekeeping (HK) genes that are strictly defined as genes that are expressed ubiquitously and consistently in most or all tissues, are under stronger translational selection.

Conclusions

These observations clearly show that translational selection is also closely associated with expression pattern. Our results suggest that

SUBMITTER: Ma L 

PROVIDER: S-EPMC4100034 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature