Lack of association between a functional polymorphism (rs1800796) in the interleukin-6 gene promoter and lung cancer.

ABSTRACT:

Background

A number of studies have examined the association between interleukin-6 (IL-6) rs1800796 polymorphism and risk of lung cancer but revealed inconsistent results. The aim of this study was to clarify the association between IL-6 rs1800796 polymorphism and risk of lung cancer.

Methods

Literature databases including PubMed, Embase and CNKI were searched up to January 2014. The pooled odds ratios (ORs) with 95% confidence intervals (CIs) under co-dominant model, dominant model and recessive model were estimated using random-effects model.

Results

A total of seven studies, including 2691 lung cancer cases and 3067 controls, were included in the meta-analysis. The results suggested that IL-6 rs1800796 polymorphism was not associated with risk of lung cancer under

SUBMITTER: Wang W 

PROVIDER: S-EPMC4100037 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature