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Pregnane-type steroids from the Formosan soft coral Scleronephthya flexilis.

ABSTRACT: Three pregnane-type steroids, including a new metabolite, 3?-methoxy-5,20-pregnadiene (1) along with two known analogues, 3?-acetoxy-5,20-pregnadiene (2) and 5?-pregna-1,20-dien-3-one (3) were isolated from the soft coral Scleronephthya flexilis. Standard spectroscopic techniques were used to determine the structure of new steroid 1. The absolute stereochemistry of steroid 2 was confirmed by X-ray diffraction analysis. Steroid 3 exhibited potent activity against MOLT-4 tumor cells.

SUBMITTER: Kuo CY 

PROVIDER: S-EPMC4100144 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature

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Pregnane-type steroids from the Formosan soft coral Scleronephthya flexilis.

Kuo Chao-Ying CY   Juan Yung-Shun YS   Lu Mei-Chin MC   Chiang Michael Yen-Nan MY   Dai Chang-Feng CF   Wu Yang-Chang YC   Sung Ping-Jyun PJ  

International journal of molecular sciences 20140606 6

Three pregnane-type steroids, including a new metabolite, 3β-methoxy-5,20-pregnadiene (1) along with two known analogues, 3β-acetoxy-5,20-pregnadiene (2) and 5α-pregna-1,20-dien-3-one (3) were isolated from the soft coral Scleronephthya flexilis. Standard spectroscopic techniques were used to determine the structure of new steroid 1. The absolute stereochemistry of steroid 2 was confirmed by X-ray diffraction analysis. Steroid 3 exhibited potent activity against MOLT-4 tumor cells. ...[more]

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