CXCR4 pathway associated with family history of melanoma.

ABSTRACT:

Purpose

Genetic predisposition plays a major role in the etiology of melanoma, but known genetic markers only account for a limited fraction of family-history-associated melanoma cases. Expression microarrays have offered the opportunity to identify further genomic profiles correlated with family history of melanoma. We aimed to distinguish mRNA expression signatures between melanoma cases with and without a family history of melanoma.

Methods

Based on the Nurses' Health Study, family history was defined as having one or more first-degree family members diagnosed with melanoma. Melanoma diagnosis was confirmed by reviewing pathology reports, and tumor blocks were collected by mail from across the USA. Genomic interrogation was accomplished through evaluating expression profi

SUBMITTER: Li WQ 

PROVIDER: S-EPMC4100594 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature