Ontology highlight
ABSTRACT:
SUBMITTER: Pasqualucci L
PROVIDER: S-EPMC4100800 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Cell reports 20140102 1
Follicular lymphoma (FL) is an indolent disease, but 30%-40% of cases undergo histologic transformation to an aggressive malignancy, typically represented by diffuse large B cell lymphoma (DLBCL). The pathogenesis of this process remains largely unknown. Using whole-exome sequencing and copy-number analysis, we show here that the dominant clone of FL and transformed FL (tFL) arise by divergent evolution from a common mutated precursor through the acquisition of distinct genetic events. Mutations ...[more]