The atypical Rho GTPase, RhoU, regulates cell-adhesion molecules during cardiac morphogenesis.

ABSTRACT: The vertebrate heart undergoes early complex morphologic events in order to develop key cardiac structures that regulate its overall function (Fahed et al., 2013). Although many genetic factors that participate in patterning the heart have been elucidated (Tu and Chi, 2012), the cellular events that drive cardiac morphogenesis have been less clear. From a chemical genetic screen to identify cellular pathways that control cardiac morphogenesis in zebrafish, we observed that inhibition of the Rho signaling pathways resulted in failure to form the atrioventricular canal and loop the linear heart tube. To identify specific Rho proteins that may regulate this process, we analyzed cardiac expression profiling data and discovered that RhoU was expressed at the atrioventricular canal during the ti

SUBMITTER: Dickover M 

PROVIDER: S-EPMC4101123 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature