Metabolome consistency: additional parazoanthines from the mediterranean zoanthid parazoanthus axinellae.

ABSTRACT: Ultra-high pressure liquid chromatography coupled to high resolution mass spectrometry (UHPLC-MS/MS) analysis of the organic extract obtained from the Mediterranean zoanthid Parazoanthus axinellae yielded to the identification of five new parazoanthines F-J. The structures were fully determined by comparison of fragmentation patterns with those of previously isolated parazoathines and MS/MS spectra simulation of in silico predicted compounds according to the metabolome consistency. The absolute configuration of the new compounds has been assigned using on-line electronic circular dichroism (UHPLC-ECD). We thus demonstrated the potential of highly sensitive hyphenated techniques to characterize the structures of a whole family of natural products within the metabolome of a marine species. M

SUBMITTER: Audoin C 

PROVIDER: S-EPMC4101514 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature