Craniofacial divergence by distinct prenatal growth patterns in Fgfr2 mutant mice.

ABSTRACT:

Background

Differences in cranial morphology arise due to changes in fundamental cell processes like migration, proliferation, differentiation and cell death driven by genetic programs. Signaling between fibroblast growth factors (FGFs) and their receptors (FGFRs) affect these processes during head development and mutations in FGFRs result in congenital diseases including FGFR-related craniosynostosis syndromes. Current research in model organisms focuses primarily on how these mutations change cell function local to sutures under the hypothesis that prematurely closing cranial sutures contribute to skull dysmorphogenesis. Though these studies have provided fundamentally important information contributing to the understanding of craniosynostosis conditions, knowledge of changes in

SUBMITTER: Motch Perrine SM 

PROVIDER: S-EPMC4101838 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature