Abdominal attacks and treatment in hereditary angioedema with C1-inhibitor deficiency.

ABSTRACT:

Background

Hereditary angioedema (HAE) is characterized by unpredictable attacks of debilitating subcutaneous and mucosal edema. Gastrointestinal attacks are painful, of sudden onset and often mistaken for acute abdomen leading to unnecessary surgery. The purpose of this study was to analyze symptom presentation of gastrointestinal angioedema in pediatric and adult HAE patients.

Methods

Information collected during the clinical development of ecallantide for treatment of acute HAE attacks included affected anatomic location, accompanying symptoms, medical history, and pain assessments. Efficacy endpoints included Treatment Outcome Score (TOS, maximum score = 100; minimally important difference = 30), a point-in-time measure of treatment response, and time to treatment respon

SUBMITTER: Rubinstein E 

PROVIDER: S-EPMC4101849 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature