Rethinking transcriptional activation in the Arabidopsis circadian clock.

ABSTRACT: Circadian clocks are biological timekeepers that allow living cells to time their activity in anticipation of predictable daily changes in light and other environmental factors. The complexity of the circadian clock in higher plants makes it difficult to understand the role of individual genes or molecular interactions, and mathematical modelling has been useful in guiding clock research in model organisms such as Arabidopsis thaliana. We present a model of the circadian clock in Arabidopsis, based on a large corpus of published time course data. It appears from experimental evidence in the literature that most interactions in the clock are repressive. Hence, we remove all transcriptional activation found in previous models of this system, and instead extend the system by including two new

SUBMITTER: Fogelmark K 

PROVIDER: S-EPMC4102396 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature