Analysis of the protein domain and domain architecture content in fungi and its application in the search of new antifungal targets.

ABSTRACT: Over the past several years fungal infections have shown an increasing incidence in the susceptible population, and caused high mortality rates. In parallel, multi-resistant fungi are emerging in human infections. Therefore, the identification of new potential antifungal targets is a priority. The first task of this study was to analyse the protein domain and domain architecture content of the 137 fungal proteomes (corresponding to 111 species) available in UniProtKB (UniProt KnowledgeBase) by January 2013. The resulting list of core and exclusive domain and domain architectures is provided in this paper. It delineates the different levels of fungal taxonomic classification: phylum, subphylum, order, genus and species. The analysis highlighted Aspergillus as the most diverse genus in terms

SUBMITTER: Barrera A 

PROVIDER: S-EPMC4102429 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature