The long and viscous road: uncovering nuclear diffusion barriers in closed mitosis.

ABSTRACT: Diffusion barriers are effective means for constraining protein lateral exchange in cellular membranes. In Saccharomyces cerevisiae, they have been shown to sustain parental identity through asymmetric segregation of ageing factors during closed mitosis. Even though barriers have been extensively studied in the plasma membrane, their identity and organization within the nucleus remains poorly understood. Based on different lines of experimental evidence, we present a model of the composition and structural organization of a nuclear diffusion barrier during anaphase. By means of spatial stochastic simulations, we propose how specialised lipid domains, protein rings, and morphological changes of the nucleus may coordinate to restrict protein exchange between mother and daughter nuclear lobes

SUBMITTER: Zavala E 

PROVIDER: S-EPMC4102450 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature