A mouse model of otitis media identifies HB-EGF as a mediator of inflammation-induced mucosal proliferation.

ABSTRACT:

Objective

Otitis media is one of the most common pediatric infections. While it is usually treated without difficulty, up to 20% of children may progress to long-term complications that include hearing loss, impaired speech and language development, academic underachievement, and irreversible disease. Hyperplasia of middle ear mucosa contributes to the sequelae of acute otitis media and is of important clinical significance. Understanding the role of growth factors in the mediation of mucosal hyperplasia could lead to the development of new therapeutic interventions for this disease and its sequelae.

Methods

From a whole genome gene array analysis of mRNA expression during acute otitis media, we identified growth factors with expression kinetics temporally related to hyperpl

SUBMITTER: Suzukawa K 

PROVIDER: S-EPMC4102546 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature