Emotional regulatory function of receptor interacting protein 140 revealed in the ventromedial hypothalamus.

ABSTRACT: Receptor-interacting protein (RIP140) is a transcription co-regulator highly expressed in macrophages to regulate inflammatory and metabolic processes. However, its implication in neurological, cognitive and emotional conditions, and the cellular systems relevant to its biological activity within the central nervous system are currently less clear. A transgenic mouse line with macrophage-specific knockdown of RIP140 was generated (MΦRIPKD mice) and brain-region specific RIP140 knockdown efficiency evaluated. Mice were subjected to a battery of tests, designed to evaluate multiple behavioral domains at naïve or following site-specific RIP140 re-expression. Gene expression analysis assessed TNF-α, IL-1β, TGF-1β, IL1-RA and neuropeptide Y (NPY) expression, and in vitro studies examined the ef

SUBMITTER: Flaisher-Grinberg S 

PROVIDER: S-EPMC4102625 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature