Squamous cell carcinoma of the oral tongue in young non-smokers is genomically similar to tumors in older smokers.

ABSTRACT:

Purpose

Epidemiologic studies have identified an increasing incidence of squamous cell carcinoma of the oral tongue (SCCOT) in younger patients.

Experimental design

DNA isolated from tongue tumors of young (<45 years, non-smokers) and old (>45 years) patients at was subjected to whole-exome sequencing and copy-number analysis. These data were compared with data from similar patients in the TCGA (The Cancer Genome Atlas) project.

Results

In this study, we found that gene-specific mutation and copy-number alteration frequencies were similar between young and old patients with SCCOT in two independent cohorts. Likewise, the types of base changes observed in the young cohort were similar to those in the old cohort even though they differed in smoking history. TCGA data al

SUBMITTER: Pickering CR 

PROVIDER: S-EPMC4102633 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature